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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GEM All Species: 21.21
Human Site: T181 Identified Species: 46.67
UniProt: P55040 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P55040 NP_005252.1 296 33949 T181 Q L R R A R Q T E D I P I I L
Chimpanzee Pan troglodytes XP_001142135 295 33821 T181 Q L R R A R Q T E D I P I I L
Rhesus Macaque Macaca mulatta XP_001087974 295 33787 T180 Q L R R A R Q T E D I P I I L
Dog Lupus familis XP_854414 517 56511 A402 Q L R R A R Q A E D I P I I L
Cat Felis silvestris
Mouse Mus musculus P55041 295 33707 T180 Q L R R A R Q T E D I P I I L
Rat Rattus norvegicus P55043 306 33020 T192 Q L R A R R Q T D V P I I L V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515756 162 18547 V69 V R S R E V S V D E G R A C A
Chicken Gallus gallus NP_998744 297 34218 K182 Q L R R A R Q K E D I P I I F
Frog Xenopus laevis Q6IP71 206 23374 R113 E F R E Q I L R V K A E E D K
Zebra Danio Brachydanio rerio NP_956092 300 34100 S185 Q L R R A R Q S E N I P I I L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48555 201 22920 I108 T Q E F R E Q I L R V K N D E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 99.3 54.1 N.A. 95.6 53.2 N.A. 44.5 82.4 26.3 59.6 N.A. 26.6 N.A. N.A. N.A.
Protein Similarity: 100 99.3 99.3 55.3 N.A. 97.6 68.3 N.A. 50 92.9 44.5 75 N.A. 41.2 N.A. N.A. N.A.
P-Site Identity: 100 100 100 93.3 N.A. 100 46.6 N.A. 6.6 86.6 6.6 86.6 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 100 66.6 N.A. 20 86.6 13.3 100 N.A. 13.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 10 64 0 0 10 0 0 10 0 10 0 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % C
% Asp: 0 0 0 0 0 0 0 0 19 55 0 0 0 19 0 % D
% Glu: 10 0 10 10 10 10 0 0 64 10 0 10 10 0 10 % E
% Phe: 0 10 0 10 0 0 0 0 0 0 0 0 0 0 10 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 10 0 10 0 0 64 10 73 64 0 % I
% Lys: 0 0 0 0 0 0 0 10 0 10 0 10 0 0 10 % K
% Leu: 0 73 0 0 0 0 10 0 10 0 0 0 0 10 55 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 10 0 0 10 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 10 64 0 0 0 % P
% Gln: 73 10 0 0 10 0 82 0 0 0 0 0 0 0 0 % Q
% Arg: 0 10 82 73 19 73 0 10 0 10 0 10 0 0 0 % R
% Ser: 0 0 10 0 0 0 10 10 0 0 0 0 0 0 0 % S
% Thr: 10 0 0 0 0 0 0 46 0 0 0 0 0 0 0 % T
% Val: 10 0 0 0 0 10 0 10 10 10 10 0 0 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _